Recent advances in microbial biosynthesis of C3 – C5 diols: Genetics and process engineering approaches

Recent advances in rational approaches for enzyme engineering

Enzymes are an attractive alternative in the asymmetric syntheses of chiral building blocks. To meet the requirements of industrial biotechnology and to introduce new functionalities, the enzymes need to be optimized by protein engineering. This article specifically reviews rational approaches for enzyme engineering and de novo enzyme design involving structure-based approaches developed in rec...

Recent advances in medical genetics.

Recent Advances in Stroke Genetics

Stroke is a complex, polygenic, and multi-factorial neurological disorder caused by a combination of environmental, vascular and genetic factors [1]. Despite new developments in the treatment and prevention, stroke accounts for the primary cause of adult disability, the second leading cause of dementia and the third leading cause of mortality in most of the developed countries [2], [3]. In the ...

Recent advances in asthma genetics

There are over 100 genes that have been reported to be associated with asthma or related phenotypes. In 2006-2007 alone there were 53 novel candidate gene associations reported in the literature. Replication of genetic associations and demonstration of a functional mechanism for the associated variants are needed to confirm an asthma susceptibility gene. For most of the candidate genes there is...

Recent Advances in Obesity: Genetics and Beyond

The prevalence of obesity, which is a heritable trait that arises from the interactions of multiple genes and lifestyle factors, continues to increase worldwide, causing serious health problems and imposing a substantial economic burden on societies. For the past several years, various genetic epidemiological approaches have been utilized to identify genetic loci for obesity. Recent evidence su...